Toronto FC will be without forward Sebastian Giovinco and defender Nick Hagglund when they take on the New York Red Bulls on Friday, May 19.
Giovinco has been diagnosed with a quad strain, according to Toronto, and will miss three weeks.
Hagglund tore the MCL in his right knee and will be sidelined 8-12 weeks, the team said.
Toronto rides their six-game winning streak into Red Bull Arena on Friday for the first matchup between the two teams this season.