Michael Amir Murillo started and went the full 90 as Panama beat Guyana, 4-2.
Panama benefitted from an own goal to go up 2-1 at half, and scored two more in the second half to win, 4-2.
Murillo and Panama sit second in Group D, behind their next opponent, the United States, each with six points. The USMNT leads on goal differential.
Panama and the US meet up on Wednesday, June 26 for the final match of the group stage.